Pressure Control for Tangential Flow Filtration - Equlibar

Pressure Control for Tangential Flow Filtration

  • Schematic of TFF process using Equilibar SDO regulator
Tangential flow filtration (TFF) is used in the biopharmaceutical industry as an efficient method for purifying biomolecules. During the process, the differential pressure across the TFF membrane must be maintained within a narrow range to provide the best results. The Equilibar® back pressure regulator with its multi-orifice design delivers superior precision and can accurately control the differential pressure across a membrane across a wide range of flow rates. The high turn-down makes the Equilibar BPR a superior choice in traditional transflow filtration control.

Schematic of TFF process using Equilibar SDO regulator

TFF Process using Equilibar SDO valves to control pressure differential across TFF membrane

In the schematic above, Equilibar® Single use pressure control valves are used in both the retentate and permeate lines of the TFF process. Setpoint signals are sent to the electro-pneumatic pilot regulators from the main control system to set the pilot pressures on the Equilibar BPRs. This setup maintains a stable target pressure differential across the filter membrane for effective TFF process results.

Equilibar single use pressure control valve was developed in response to the biopharma industry’s rapidly expanding requirements for low cost components that can be sterilized through radiation and disposed of after use. It is also appropriate for other service conditions that require single use components.

The valve’s patent pending design offers USP Class VI polymers that can be sterilized as an assembly. The Single Use Equilibar features the same dome-loaded multiple orifice technology as all Equilibar patented products, delivering instantaneous control, frictionless operation, superior precision, and exceptionally wide flow rate ranges. Its strengths are particularly well suited to control the transmembrane pressure in tangential flow filtration control applications.

 

 

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Learn more about our back pressure regulator technology and about other Equilibar products designed for use in sanitary process.

Contact one of our applications engineers to help select the perfect back pressure regulator for your filtration application.

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