Many BioPharma processes require precise dosing and blending of Water-For-Injection (WFI), nutrients, and other buffer solutions as input to a reactor, fermenter, or chromatography column. These dosing or blending systems must often be able to control over a wide range of flow rate to hold the desired conditions in the downstream process.
Traditional dosing systems in BioPharma utilize flow control valves such as a diaphragm weir style or a globe or needle style body with sanitary fittings. These valves typically provide stable control through only a 15:1 flow rate range, and process engineers must often install multiple flow control valves in parallel to achieve the needed wide dosing range.
The Equilibar® Sanitary Back Pressure Regulator works across a very wide range of flow rate, and can be used to enhance dosing flow rate control in BioPharam processes in several ways:
Stabilize Downstream Pressure of Dosing Valve
Dosing valves often suffer from unexpected pressure changes downstream, which take time for the PID controller to adjust to. In other situations, dosing control valves are not able to function through the required flow rate range because of undesired pressure changes downstream. The Equilibar sanitary back pressure regulator has been used to isolate flow control valves from downstream pressure fluctuations.
Function as 100:1 Flow Metering Valve
The Equilibar back pressure regulator can often function in place of a traditional flow control valve, and in many applications control flow rate through a 100:1 turndown range. While pressure changes downstream of the BPR are generally isolated and have no impact, it should be noted that this approach does require a stable upstream fluid pressure source. See video and application notes.
Precisely Control Pump Discharge Pressure
Regardless of the type of pump used, a precision back pressure regulator can be used to control its discharge pressure when a circulating loop in installed. A manually controlled back pressure regulator could be used to maintain the desired stable pressure to enhance the control valve performance. In addition, an electronic back pressure regulator can be used to actually control the flow rate of the dosing process (for example, across a fixed orifice or a spray nozzle). See pump discharge pressure control application notes
When a process calls for WFI to rinse the bioreactor out, the pharmaceutical engineer will set up the dosing system for that particular WFI flow rate. When complete, the engineer will switch back to a setup for dosing low flow bioreactor components for production. Using the Equilibar back pressure regulator in this application will allow for dosing and CIP across a wide flow range (in the 1000:1 range for some applications), and thus prevent the unnecessary switching of equipment. This design can be applied to other systems such as upstream / downstream filtration, chromatography columns, and much more. The sanitary design of the Equilibar FD series and the high Cv window allow for the BPR to control precisely during production and to flow freely during CIP/SIP, preventing undesired restriction during these cleaning processes.
- Port Sizes:
- Typical Pressure Ranges:
- 0 - 1 in WC
- 0 - 28 in WC
- 0 - 5 psi
- 0 - 10 psi
- 0 - 20 psi
- 0 - 30 psi
- 0 - 60 psi
- 0 - 100 psi
- 0 - 150 psi
- Key Applications:
Contact one of our Applications Engineers to help select the perfect back pressure regulator for your filtration application.