Pressure Control for Biopharmaceutical Filtration

  • Equilibar schematic membrane separation

Filtration is a key step in the manufacturing of biopharmaceutical products. Upstream filtration may prepair media or buffer solutions, while downstream filtration typically involves purification focused on isolating the target molecules or compounds.

Depending on the targeted molecules, the differential pressure across the filter or separation membrane must be carefully maintained in a narrow range. Many small molecule separations require transmembrane pressures in the range of 1 psi. Downstream filtration, where purity requirements are higher than upstream, rely on accurate pressure control within this narrow range along with a sanitary design.

The Equilibar dome-loaded back pressure regulator may be used to accurately control the differential pressure across a diaphragm or membrane separator across a wide range of flow rates. Our FD series of sanitary back pressure regulators are ideal for upstream or downstream biopharmaceutical filtration application. These regulators are made of SS316L and can be fitted with USP Class VI diaphragms. They offer a crevice-free design, and in certain orientations are fully drainable.


Sanitary back pressure regulator ( product details)

Product Details

FDO8 Sanitary Back Pressure Regulator

FDO8 Sanitary Back Pressure Regulator

Port Sizes:
Typical Pressure Ranges:
0 - 1 in WC
0 - 28 in WC
0 - 5 psi
0 - 10 psi
0 - 20 psi
0 - 30 psi
0 - 60 psi
0 - 100 psi
0 - 150 psi
Key Applications:
  • Liquid blending and dosing
  • Biopharma manufacturing
  • Sanitary Tank Blanketing
Technical Details

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Learn more about our back pressure regulator technology and how it works.

Contact one of our Applications Engineers to help select the perfect back pressure regulator for your filtration application.

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Equilibar News

flow control white paper Equilibar ILS

New White Paper Focuses on Flow Control Setup at Integrated Lab Solutions

A new white paper explains how an Equilibar® can be used in combination with a mass flow sensor to provide reliable flow control for particularly difficult research applications. While Equilibar’s ability to provide excellent pressure control is well known, fewer scientists and engineers are familiar with using it for flow control, making the paper especially […]

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