Filtration is a key step in the manufacturing of biopharmaceutical products. Upstream filtration may prepair media or buffer solutions, while downstream filtration typically involves purification focused on isolating the target molecules or compounds.
Depending on the targeted molecules, the differential pressure across the filter or separation membrane must be carefully maintained in a narrow range. Many small molecule separations require transmembrane pressures in the range of 1 psi. Downstream filtration, where purity requirements are higher than upstream, rely on accurate pressure control within this narrow range along with a sanitary design.
The Equilibar dome-loaded back pressure regulator may be used to accurately control the differential pressure across a diaphragm or membrane separator across a wide range of flow rates. Our FD series of sanitary back pressure regulators are ideal for upstream or downstream biopharmaceutical filtration application. These regulators are made of SS316L and can be fitted with USP Class VI diaphragms. They offer a crevice-free design, and in certain orientations are fully drainable.
Contact one of our Applications Engineers to help select the perfect back pressure regulator for your filtration application.