Pressure Control for Biopharmaceutical Filtration -

Pressure Control for Biopharmaceutical Filtration

Trans flow and cross flow biopharmaceutical filtration

  • Equilibar schematic membrane separation
Filtration is a key step in the manufacturing of biopharmaceutical products. Upstream biopharmaceutical filtration may prepare media or buffer solutions, while downstream filtration typically involves purification focused on isolating the target molecules or compounds. In these steps, the differential pressure across the filter or separation membrane must be carefully maintained in a narrow range.

The Equilibar® dome-loaded back pressure regulator (BPR) offers higher turndown ratio than other valves and can therefore provide precise control across a wide range of flow rates. This makes the Equilibar BPR a superior choice in traditional trans flow or cross flow filtration control.

Our FD series of sanitary BPRs are designed specifically for these applications in which sanitary biopharma equipment must be used. These FD BPRs are made of SS316L and are fitted with USP Class VI diaphragms. They have a crevice-free design and are drainable in certain orientations.

Schematic of Cross Flow Filtration using Equilibar Sanitary back pressure regulator

In the biopharmaceutical filtration system schematic above, an Equilibar FD BPR is used in both the retentate and permeate lines at the exit of the trans flow filtration membrane. A setpoint is established on the dome of the BPR using an electro-pneumatic pilot regulator so the Equilibar FD valve can be computer controlled. This allows the filtration system to be controlled by differential pressure (dP) mode – the pressure differential between the feed and retentate streams; by transmembrane pressure (TMP) mode – adjusts the retentate control valve to maintain constant TMP; or cross flow rate (flux) mode – flow is maintained by regulating the retentate and permeate flow. In flux mode, the Equilibar FD back pressure regulators act as flow control valves. The precise and instantaneous control of the Equilibar back pressure control technology make them well suited for biopharmaceutical filtration.

FD Series Sanitary back pressure regulator designed with ASME BPE in mind. ( product details)

Product Details

FDO8 Sanitary Back Pressure Regulator

FDO8 Sanitary Back Pressure Regulator

Port Sizes:
Typical Pressure Ranges:
0 - 1 in WC
0 - 28 in WC
0 - 5 psi
0 - 10 psi
0 - 20 psi
0 - 30 psi
0 - 60 psi
0 - 100 psi
0 - 150 psi
Key Applications:
Technical Details

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Learn more about our back pressure regulator technology and how it works.

Contact one of our application engineers to help select the perfect back pressure regulator for your filtration application.

Watch the video below of how the Equilibar Back Pressure Regulator works.

How Equilibar Back Pressure Regulator Works

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Jeff Jennings, Equilibar president, with schematic

Seven Ways to Dome Load

Equilibar’s back pressure regulators (BPRs) are dome loaded.  This means that the pressure setpoint is provided by a fluid that is fed into a chamber on the top (dome) of the regulator. The pressure of the fluid (either gas or liquid) is set by a second regulator called a pilot regulator.  The loading mechanism is Read More

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