Equilibar Single Use | Precision Fluid Control

Equilibar Single Use Products

Single Use Valve Technology for BioPharmaceutical Processing

Equilibar offers a line of products designed to accommodate the rapidly expanding single use technology (SUT) field in the biopharmaceutical industry. Single use systems (SUS) require lower cost components that can be sterilized through irradiation and disposed of after their useful life.

Single Use Valve

The Equilibar® dome loaded multi-orifice valve technology is now available in a single use valve. The patent pending Equilibar® SD series single use valves are manufactured using USP Class VI polymers and stainless steel. The disposable valve body made of polymer is inserted into a stainless steel support housing with wing nut closure for quick and easy assembly. The Equilibar single use valve for bioprocessing systems is a revolutionary design in single use pressure control.

Alternative to a Pinch Valve

Single-Use Pinch valves use external mechanical compression over existing product tubing to control flow and pressure through a single use process line. The Equilibar single use valve is a very precise alternative to a pinch valve. Its award-winning design allows it to be configured for precision pressure regulation or for closed loop flow control. Compared to a pinch valve, the SDO single use back pressure regulator responds to fluctuations more quickly and reaches the desired setpoint swiftly.

Applications

bioreactor with tangential flow filtration controlled by single use SDOTangential flow filtration pressure control

READ MORE

Equilibar SDO valve controlling diaphragm pump outlet pressure for proper NPSHMinimize pump push-through from NPSH READ MORE

disc stack centrifuge centrate pressure control schematicDisc stack pressure control READ MORE

Schematic of Equilibar Single use BPR with an E+H Promass single use flow meterWFI Point-of-Use flow control

READ MORE

How it Works

The SD regulator features Equilibar’s patented dome-loaded multiple orifice technology delivering instantaneous control, frictionless operation and superior precision across exceptionally wide flow rate ranges. The stainless steel housing is designed as a permanent part of the process and connects to a dome pilot pressure supply. The disposable body is sold in a pre-sterilized state and comes ready for sterilization up to 50 kGy. See Sample Certificate of Conformance.

how Equilibar works sanitary

Once assembled, simply apply a pressure to the pilot port in the dome of the Equilibar valve equal to the desired setpoint and the valve does the rest. This pilot pressure forces the upper flexible diaphragm down onto a field of orifices. A rise in inlet pressure lifts the diaphragm up to allow excess pressure to be relieved through the outlet orifices. Similarly, a loss of pressure at the inlet causes the diaphragm to be pushed closer to the orifices, restricting flow and rebuilding pressure at the inlet.

Its strengths are particularly well suited to control the transmembrane pressure in tangential flow filtration or cross-flow filtration, and dP control in virus filtration systems.

The video demonstrates the stability and precision control of the Equilibar single use back pressure regulator

In addition to pressure control applications, the Equilibar SD can be used in on/off and flow control applications in single use processes. Potential advantages for on/off applications include the simple construction, ease of computer automation and low pressure drop. The Equilibar SD Single Use valve can control flow across a wider range of flow than other designs and is extremely responsive. Buffer delivery systems in gradient elution applications can benefit from using the Equilibar SD valve to control flow for precision blending.

Equilibar single use back pressure regulator with consumable body

Download a BrochureSpeak to an Engineer

Looking for Multi-Use Sanitary Valves?

Visit Multi-Use Sanitary

PRODUCTS IN THIS SERIES

SDO1 Single Use Valve 1/8” barb hose fitting

View Product

 

SDO2 Single Use Valve 1/4” barb hose fitting

View Product

 

SDO3 Single Use Valve 3/8” barb hose fitting

View Product

 

SDO4 Single Use Valve 1/2” barb hose fitting

View Product

 

SDO6 Single Use Valve 3/4” barb hose fitting

View Product
Equilibar SDO8 single use valve

SDO8 Single Use Valve 1” barb hose fitting

View Product


SD Series Specifications

graph of flow curve for SDO6

Download a brochure or contact an Equilibar applications engineer for more information

Download Brochure

 


Looking for a pulsation dampener for single use bioprocessing?

Equilibar engineers have leveraged their fluid control knowledge to design an active pulsation dampener for single use bioprocessing systems. This single use pulsation dampener uses pneumatics and self-adjusts its setpoint to match system pressure in real time to dampen pulsations. This behavior is similar to how the Equilibar SDO back pressure valve dampens pulsations, but is optimized for this dedicated dampening device.

The non-wetted sides of the diaphragms are pressurized with air through a pressure regulator connected to a port on the top and bottom of the stainless steel housing. This patented air balancing system adjusts its internal pressure in response to the force and direction of each pump pulsation against the diaphragms, reducing pulsation amplitude. Early trials have shown >70% reduction on amplitude, and establishes a more uniform pressure profile.

Learn More

Interested in a precision single use flow control valve?

Using the same valve body, cradle and consumable insert as our Single Use Back Pressure Regulator, the Equilibar valve can be used as an advanced flow control valve for single use bioprocessing systems. The valve is set up in a closed loop configuration with the electronic pilot pressure regulator (E/P) and a flow meter in a feedback control loop.

single use flow control valve

A proportional-integral-derivative (PID) controller monitors the input from the flow transmitter (FT) and adjusts the pilot pressure to control flow. The E/P translates the electronic signal from the PID into a pressure signal to control the pilot pressure.

This unique configuration offers precision control with 100:1 flow turndown that can’t be matched by automated pinch valves, or automated weir style single use valves.

Learn More



Equilibar News
Equilibar back after Hurricane Helene

The Equilibar team is back at work after Hurricane Helene

We’re happy to report that the Equilibar team is fully back at work this week following Hurricane Helene. While Helene wreaked havoc across the Western North Carolina mountains, we feel extremely lucky that all of our team members and their families are safe and our facilities had only minor issues. Once we could return to Read More

Read More