{"id":38518,"date":"2023-01-31T17:12:28","date_gmt":"2023-01-31T21:12:28","guid":{"rendered":"https:\/\/www.equilibar.com\/?page_id=38518"},"modified":"2025-11-24T16:22:27","modified_gmt":"2025-11-24T20:22:27","slug":"single-use-pulsation-dampener","status":"publish","type":"page","link":"https:\/\/www.equilibar.com\/it\/single-use\/single-use-pulsation-dampener\/","title":{"rendered":"Single Use Pulsation Dampener for Biopharma"},"content":{"rendered":"

What is the purpose of a pulsation dampener?<\/h3>

A pulsation dampener is used to improve process effectiveness by reducing pulsating flows caused by positive displacement pumps. Dampeners reduce pulsations to ensure a smooth fluid flow so that processes downstream of the pump are accurate, efficient and safe. Pulsation dampening is particularly important in biopharmaceutical processing due to the sensitivity of the cells (upstream), and biomolecules (downstream) to changing process conditions. Single use systems (SUS) benefit from using pulsation dampeners during media transfer, perfusion, filtration, chromatography and other processes.<\/p>

What are the challenges caused by pulsations in bioprocessing?<\/h3>

In bioprocessing, pulsations caused by positive displacement pumps (peristaltic, diaphragm, and others) can create upstream and downstream processing challenges including:<\/p>

  • Difficulty in measuring flow accurately, affecting process control<\/li>
  • Stress on delicate cells or biomolecules<\/li>
  • Decreased filtration effectiveness due to variability in TMP<\/li>
  • Disturbances in chromatography resin<\/li>
  • Possible Inaccuracies in filling<\/li> <\/ul>

    All of these situations cost time and money or affect product yield \/ quality, so keeping them to a minimum is important.<\/p> <\/div>

    \"Equilibar

    Equilibar patented active pulsation dampener for single use bioprocessing<\/p><\/div>

    Speak to an Engineer<\/a><\/p> <\/div><\/div>

    How to control pulsations in single use bioprocessing<\/h3>

    Process pulsations can be reduced by adding a pulsation dampening device downstream of the pump. Equilibar engineers have leveraged their fluid control knowledge to design a pulsation dampener for single use bioprocessing systems.<\/p>

    This unique, non-restrictive device reduces system flow and pressure pulsations using a Class VI polymer single-use hollow body between two integrated diaphragms that face process pressure. The polymer body is enclosed in a permanent stainless steel housing with wing nut closure for easy change-outs.<\/p>

    The Equilibar\u00ae single use pulsation dampener uses pneumatics and self-adjusts its setpoint to match system pressure real-time to dampen pulsations. This behavior is similar to how the Equilibar SDO back pressure valve dampens pulsations, but is optimized for this dedicated dampening device.<\/p>

    The non-wetted sides of the diaphragms are pressurized using a pressure regulator connected to a port on the top and bottom of the stainless steel housing. This patented system will adjust its internal pressure in response to the force and direction of each pump pulsation against the diaphragms, reducing pulsation amplitude. Early trials have shown >70% reduction on amplitude, and establishes a more uniform pressure profile.<\/p>

    What is different about the Equilibar pulsation dampener?<\/h3>

    This dampening device, when compared to other single use dampeners, actively responds to pulsations which improves dampening capabilities compared with passive dampening devices. Furthermore, it\u2019s compact size significantly reduces footprint, which makes it much easier to integrate. The Equilibar pulsation dampener has optimal performance in any orientation.<\/p>

    CONTACT US for more information<\/a> or to discuss a trial.<\/p>

    W<\/span>atch how an Equilibar single-use pulsation dampener can reduce pump-induced pulsations by 10x!<\/span><\/p>